“Fading puppy syndrome" poses a significant threat to the health and survival of newborn puppies, particularly within the first two weeks of life. This syndrome encompasses various factors contributing to a failure to thrive, including genetic, environmental, and maternal influences. Breeders must be vigilant in identifying subtle signs such as weakness, low birth weight, and decreased appetite. Understanding the causes and risk factors allows for proactive prevention measures, including proper breeding practices, prenatal care, and maintaining a clean and warm whelping environment. Prompt veterinary intervention and supportive care are essential for at-risk puppies. By implementing these strategies, breeders can increase the chances of nurturing a robust and healthy generation of Doodles, minimizing the impact of fading puppy syndrome.